Scientific Program

LOCATION: All events will take place at SUSB (Building 53) unless otherwise noted in the program booklet.

Scientific Program (PDF):  Download the BSR 2016 Scientific Program here.

BSR Abstract Booklet (PDF): Download the BSR 2016 Abstract Booklet here.

List of Posters (Presentation Order; PDF):  Download the BSR 2016 Poster Session list here (presentation order).

List of Posters (Alphabetical Order; PDF):  Download the BSR 2016 Poster Session list here (alphabetical order).


Sunday, August 21, 2016
Arrival and Registration   15:00-17:00
Reception   17:00-19:00
Monday, August 22, 2016
Soichi Wakatsuki, Stephen Burley, Mike Dunne, Kelly Gaffney, and Henry van den Bedem Welcome 08:15-08:30
Membrane Proteins (Chair: Poul Nissen)
Poul Nissen, Aarhus University Introduction 08:30-08:35
Zhi-Jie Liu, iHuman Institute

Structural and functional studies of Human GPCRs

Brian Kobilka, Stanford University The dynamic process of G protein activation 08:55-09:15
Irmgard Sinning, Heidelberg University Regulation of protein targeting: when SRP meets the ribosome 09:15-09:35
Jian-Ren Shen, Okayama University High resolution structure of photosystem II and the mechanism of photosynthetic water-splitting 09:35-09:55
Liz Carpenter, University of Oxford Structure and function of K2P ion channels from synchrotron data from Diamond and serial femtosecond crystallography at LCLS 09:55-10:15
Alexander Kintzer, UCSF Structure, inhibition, and regulation of a 
two-pore channel TPC1
Break / Group Photo   10:30-11:00
Macromolecular Complexes (Chair: Bill Weis)
Bill Weis, Stanford University Introduction 11:00-11:05
Osamu Nureki, University of Tokyo Structure-based development of genome-editing tool, CRISPR-Cas9 towards medical applications 11:05-11:25
Richard Garratt, University of São Paulo Septins, a molecular jigsaw 11:25-11:45
Yvonne Jones, University of Oxford Cell surface signaling systems, structural insights in developmental biology 11:45-12:05
Jim Hurley, UC Berkeley   12:05-12:25
Natalie Strynadka, University of British Columbia

Structure-based piecing together of the Type III secretion system puzzle

Karthik Sathiyamoorthy, Stanford University Structural Basis for Epstein-Barr Virus Host Cell Tropism mediated by gp42 and gHgL Entry Glycoproteins 12:45-13:00
Lunch Break/Poster Setup   13:00-14:30
Poster Session 1   14:30-16:00
Hybrid Methods (Chair: Robert McKenna)
Robert McKenna, University of Florida Introduction 16:00-16:10
Gabriel Waksman, University College London/Birkbeck Structural and Molecular Biology of Bacterial Secretion Systems 16:10-16:30
Jill Trewhella, University of Sydney Small-Angle Scattering: an Effective Constraint in Modelling Complex Biomolecular Structures 16:30-16:50
Mike Hough, University of Essex

Fingerprinting Redox and Ligand States in Protein Crystals: Applications for Validation and Determining Structural Movies

Flora Meilleur, Oak Ridge National Laboratory Radiation damage free structural studies of cellulolytic redox enzymes using neutron scattering and diffraction 17:10-17:30
Martin Beck, EMBL Heidelberg In situ structural analysis of the human nuclear pore complex 17:30-17:50
Hélène Déméné, CNRS Towards a Mechanistic Understanding of the Opioid Mu Receptor Activation 17:50-18:10
Orion Shih, NSRRC Linear Oligomerization Process of BAX Revealed from Coexisting Intermediates in Solution 18:10-18:30
Tuesday, August 23, 2016
Bioinformatics and Computing (Chair: Helen Berman)
Helen Berman, Rutgers University - Introduction Introduction 08:30-08:35
Michael Levitt, Stanford University School of Medicine Combinatorial methods solve a difficult structural problem to reveal how chaperonins work in eukaryotes 08:35-08:55
Christine Orengo, University College London CATH-FunFams: New domain families to explore protein structure and function space 08:55-09:15
Paul Adams, Lawrence Berkeley National Laboratory New methods for low resolution structure refinement 09:15-09:35
Dan Rigden, University of Liverpool Exploiting structural bioinformatics for unconventional molecular replacement 09:35-09:55
Wladek Minor, University of Virginia

High throughput computing on high output synchrotron facilities

Daniel Franke, EMBL-Hamburg Rapid Shape Classification of Biological 
Macromolecules from Small Angle X-ray Scattering Data
Break   10:30-11:00
Science with Upgraded SRS (Chair: Stefan Vogt)
Stefan Vogt, Argonne National Laboratory Introduction 11:00-11:10
Pieter Glatzel, ESRF Hard X-ray photon-in/photon-out spectroscopy at ESRF-EBS 11:10-11:30
Marjolein Thunnissen, MAX IV Laboratory

Possibilities for the Life Sciences at the first diffraction limited light-source MAX IV

Gayle Woloschak, Northwestern University

Upgrading X-ray fluorescence imaging

Lin Yang, Brookhaven National Laboratory The Life Science X-ray Scattering (LiX) Beamline at NSLS-II 12:10-12:30
Lunch Break/Poster Setup   12:30-14:00
Poster Session 2   14:00-15:30
Industrial or Pharmaceutical Applications (Chair: Nigel Walker)
Nigel Walker, Molecular Consulting - Introduction The application of structural biology to pharmaceutical drug discovery 16:00-16:10
Benjamin Bax, GlaxoSmithKline, UK How is movement coupled to catalysis in DNA gyrase? 16:10-16:30
Chun-Wa Chung, GlaxoSmithKline R&D, UK How crystallography can (and can’t) help us find drugs 16:30-16:50
Avni Bhatt, University of Florida Crystallographic insight into enhanced catalytic activity of carbonic anhydrase II using “activating” ligands 16:50-17:10
SLAC Tour - Pre-registration required   17:10-19:00
BBQ - Pre-registration required   19:00-22:00
Wednesday, August 24, 2016
X-ray/IR Imaging/SR-CDI (Chair: Chris Jacobsen)
Chris Jacobsen, Argonne National Laboratory Introduction 08:30-08:35
Tanja Dučić, CELLS-ALBA Multimodal synchrotron spectro-microscopy for elucidation cellular disorders in neuro-degenerative diseases 08:35-08:55
Liz Duke, Diamond Light Source Cryo Soft X-ray Microscopy: New Opportunities for Structural Biology 08:55-09:15
Patrick La Riviere, University of Chicago Development of “color” x-ray histology using multiple metal stains and multi-energy synchrotron CT 09:15-09:35
Andreas Menzel, Paul Scherrer Institute Bio-Imaging using X-Ray Ptychography - The Method, Recent Advances, and Applications 09:35-09:55
Carol Hirschmugl, University of Wisconsin - Milwaukee Rapid 2D and 3D IR imaging Applied to Biologically and Chemically Complex Systems 09:55-10:15
Michael Martin, LBNL Biological SINS: Broadband synchrotron infrared nano-spectroscopy of biological materials 10:15-10:30
Break   10:30-11:00
Dynamics (Chair: Keith Moffat)
Keith Moffat, University of Chicago Introduction 11:00-11:05
Marius Schmidt, University of Wisconsin - Milwaukee

Ultrafast Dynamics in Proteins Investigated by Time-Resolved Serial Femtosecond Crystallography

Lois Pollack, Cornell University Time-resolved studies: SAXS of protein-DNA complexes and mixing jets for XFELs 11:25-11:45
Rajmund Mokso, MAX IV Laboratory Fast tomographic microscopy to capture the dynamics of life 11:45-12:05
Doeke Hekstra, UT Southwestern Probing the mechanics of molecular machines with electric fields and X-rays 12:05-12:25
James Fraser, UC San Francisco

Birth of the Cool: Multitemperature Multiconformer X-Ray Crystallography

Daniel Keedy, UCSF Multitemperature synchrotron crystallography and ligand scanning reveal novel allosteric modulators of the therapeutic target PTP1B 12:45-13:00
Lunch Break/Poster Setup   13:00-14:30
Poster Session 3   14:30-16:00
7 Years of XFEL in Structural Biology (Chair: Janet Smith)
Janet Smith, University of Michigan Introduction 16:00-16:10
Richard Neutze, University of Gothenburg

Time-Resolved serial femtosecond crystallography studies of bacteriorhodopsin - a light-driven proton pump.

Ilme Schlichting, Max Planck Institute for Medical Research

Phasing Serial Femtosecond Crystallography data

Henry Chapman, DESY Macromolecular Diffractive Imaging using Disordered Crystals 16:50-17:10
Axel Brunger, Stanford University XFEL crystal structure of the Synaptotagmin-1 : SNARE complex 17:10-17:30
So Iwata, RIKEN SPring-8 Center/Kyoto University

Macromolecular Crystallography at SACLA

Andy Aquila, SLAC National Accelerator Laboratory Single Particle Imaging at the Linac Coherent Light Source 17:50-18:10
Jan Kern, LBNL Mechanism of Water Oxidation in Photosystem II Studied by Room Temperature fs X-ray Crystallography and Spectroscopy 18:10-18:30
Soichi Wakatsuki and Stephen Burley Closing Remarks 18:30-19:00